Pedigree of the 2 CVID families investigated.

Genetic trees of family 1 and family 2 are shown in panels A and B, respectively. Patients are labeled with numbers and letters as indicated in the text. An arrow indicates patients analyzed for the presence of SH2D1A gene mutations. (box) Males; (circle) females; (line through) deceased; (filled) affected male; (dotted) patient carrier; (open) unaffected subjects.