Fig. 7.
Expression and function of CX3CR1 by Th lymphocytes.
Expression of CX3CR1 by CD45RO+ (A) and CD45RO− (D) Th lymphocytes was evaluated by flow cytometry. Six healthy individuals (controls) and 14 HIV-infected patients were analyzed. Results correspond to the fraction (mean ± SEM) of CD4+ T lymphocytes expressing CX3CR1. The response of CD45RO+ (B,C) and CD45RO− (E,F) Th lymphocytes following addition of FKN (B,E) or SLC (C,F) was evaluated by determining the kinetics of actin polymerization in 10 healthy individuals (empty circles) and in HIV-infected individuals (full circles). A total of 38 and 9 HIV-infected patients were tested for response to FKN and to SLC, respectively. *P = .01 (comparison between HIV-infected patients and controls, ttest).