American Society of Hematology

Fig. 3.

$Fig. 3. Effects of alanine-substituted FANCCmutations on activation of FANCD2. / The indicated lymphoblast lines were lysed and fractionated into cytoplasmic and nuclear fractions. Equal amounts from each fraction were analyzed by immunoblotting with antibody against FANCD2. The high-molecular-weight isoform, FANCD2-L, represents the activated FANCD2. All samples were analyzed for β-tubulin levels to ensure effective cellular fractionation.$

Effects of alanine-substituted FANCCmutations on activation of FANCD2.

The indicated lymphoblast lines were lysed and fractionated into cytoplasmic and nuclear fractions. Equal amounts from each fraction were analyzed by immunoblotting with antibody against FANCD2. The high-molecular-weight isoform, FANCD2-L, represents the activated FANCD2. All samples were analyzed for β-tubulin levels to ensure effective cellular fractionation.

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