The onset of donor RBC chimerism and decline in antidonor isohemagglutinin levels after NST compared with myeloablative SCT.

The onset of donor RBC chimerism and decline of host antidonor isohemagglutinins to clinically insignificant levels were markedly delayed following major ABO-incompatible NST compared with myeloablative SCT. NST data are represented by solid squares; myeloablative SCT data, by open circles. (A) Kaplan-Meier plot of the percentage of patients without detectable donor RBC chimerism as a function of days after transplantation. The time until detection of donor RBC chimerism was significantly prolonged following NST versus myeloablative SCT; P < .0001. (B) Kaplan-Meier plot showing the percentage of patients with persistent host antidonor isohemagglutinins greater than 1+ in strength. Isohemagglutinins decreased significantly faster after myeloablative SCT than after NST;P = .012.