Correlation of the onset of donor RBC chimerism with a decline in host antidonor isohemagglutinins after major ABO-incompatible NST.

Following major ABO-incompatible NST, the onset of donor RBC chimerism was strongly correlated with a decline in host antidonor isohemagglutinins to 1+ or lower, and the time until isohemagglutinins decreased to levels 1+ or lower was related to the pretransplantation isohemagglutinin titer. (A) The onset of donor RBC chimerism after NST strongly correlated with a decline in host isohemagglutinins to clinically insignificant levels (1+ or lower on reverse type;R² = 0.72; P < .0005). (B) The time until host antidonor isohemagglutinins decreased to levels 1+ or lower correlated with the log value of the pretransplantation isohemagglutinin titer (R² = 0.56;P = .02).