Comparison between RD114- and GALV-pseudotype vectors in a competitive repopulation assay in dogs.

Detection of vector sequences in peripheral blood cells from dogs E523 (A) and E695 (B) transplanted with CD34-enriched marrow cells transduced with either RD114-pseudotype vectors produced from a high-titer clone of a human packaging cell line (LgGLSN), by a low-titer clone of the same human packaging cell line (LNX), or by GALV-pseudotype vectors produced by a mouse packaging cell line (LNY). Percentage of vector-positive DNA as measured by phosphor image analysis of signal intensities for LNY, LNX, and LgGLSN corrected for the amount of DNA and the number of experimental arms.