Compilation of TCRD recombination patterns.

Indicated are the parts of the TCRD locus that can rearrange in the E2A and HEB transfectants described in this study, CD34⁺/CD1a⁻ and CD34⁺/CD1a⁺ thymocyte subsets, CD3⁻ and TCRγδ and TCRαβ T-ALL, and precursor B-ALL. The pattern observed in the E2A/HEB-plus-RR–transfected cells is strikingly similar to that of the most immature thymocytes and the cross-lineage pattern of precursor B-ALL, illustrating that E2A and HEB can induce the immature and less T-cell–specific rearrangements in theTCRD locus.