Fig. 3.
In situ hybridization for MV nucleocapsid (N) mRNA in ARH-77 tumor xenografts treated with MV-Edm.
(A) Tumor injected with UV-inactivated measles virus stained negative for MV-N mRNA. (B) Tumor injected directly with a single dose of 107 pfu active MV-Edm and harvested 3 days later showed positive (dark purple) staining in tumor cells/syncytia, indicating viral replication. (C) Higher magnification of boxed area. (D) Tumor harvested 7 days after mouse was injected intravenously through the tail vein with 1 dose of 107 pfu active MV-Edm also showed positive staining for MV-N mRNA in the tumor tissue.
