Fig. 5.
BALB/c mice immunized with intact bsAb BiLu and irradiated A20-EpCAM cells successfully reject A20 wild-type challenge.
Mice were immunized as indicated in Figure 4 with bsAb (▪) or bsF(ab′)2 fragments (♦) and irradiated A20-EpCAM cells. The control group was treated only with irradiated tumor cells without bsAb (+). The CD4 depletion group (■) was identically treated to the bsAb group but injected with CD4+ T-cell–depleting CD4.2 antibody. In 2 independent experiments similar data were obtained.
