Kaplan-Meier analysis of cumulative survival of mice bearing Ramos lymphoma xenografts treated with conventional or pretargeted RIT.
Groups of 8 to 10 mice bearing 50 to 300 mm3 Ramos tumor xenografts were treated as described in the legend to Figure 5and analyzed serially for survival as a function of time. Treatment groups included 800 μCi 90Y-DOTA-biotin alone (A), 1.4 nmol control conjugate NR-LU-10-SA, followed 24 hours later by 5.8 nmol CA and 3 hours after that with 800 μCi 90Y-DOTA-biotin (B), with 1.4 nmol directly radiolabeled 90Y-DOTA-1F5 labeled with either 200 μCi (C) or 400 μCi of 90Y (D), or with 1.4 nmol anti-CD20 immunoconjugate 1F5-SA followed 24 hours later by 5.8 nmol CA, and 3 hours after that with 400 μCi (E) or 800 μCi (F) 90Y-DOTA-biotin (lines B and D overlap extensively).
