Fig. 7.
Loss of Atm augments lethal myelosuppression.
The survival of C57Bl/6 mice receiving bone marrow transplants fromAtm−/− (ATM KO, n = 8),p53−/− (p53 KO, n = 7),p53+/− (p53 HZ, n = 6), or wild-type (WT, n = 7) bone marrow. Mice receiving Atm−/−,p53+/−, and wild-type marrow transplants were given PEG-rmMGDF intravenously after exposure to the lethal myelosuppressive regimen.