Evaluation of various schemas for the administration of IL-10 in tumor protection models involving vaccination with peptide-pulsed DCs.

(A) Fundamentally, we evaluated several tumor challenge models involving DC vaccination. We compared the various indicated application schedules for IL-10 administration in such models. (B) EG.7-OVA tumor growth in vaccinated mice was evaluated for each of these treatment schemas. In group 5, tumors grew transiently but decreased afterward, whereas in other groups tumors grew progressively. In groups 2 and 3, tumors grew progressively after 30 days. These data represent the mean tumor area for 5 mice per group. Standard deviations were less than 15%. This experiment was performed 3 times, with comparable data obtained in each experiment.