IL-10 potentiates the efficacy of adoptively transferred activated OT-1 T cells (CTLs).

Activated OT-1 T cells were generated from OT-1 spleen by culturing with peptide for 36 hours before adoptive transfer into syngeneic mice. In some groups, systemic IL-10 was then provided. IL-10 administration provided after adoptive transfer of activated OT-1 T cells significantly restricted tumor (EG.7-OVA) growth, suggesting that they showed CTL activity. These data represented the mean of 3 mice. Standard deviations were less than 10%. (OVA-specific CTLs were described as activated T cells. Activated T–IL-10–EG7 indicates the sequence of injected events.)