Apo2L and Fas induce apoptosis.

(A). U266 (left) and RPMI-8266 (right) were treated with Apo2L and anti–Fas mAb (CH 11) and examined for induction of apoptosis by Hoechst staining. U266 (B) and primary MM plasma cells (C) were treated with Apo2L for 48 hours and then subjected to Western blotting for caspase 3 and Bcl-2. The concentration of Apo2L and Fas is given as ×100 ng/mL.