Differentiation and lineage bifurcation model between osteoclasts and dendritic cells from common precursor cells (c-Kit⁺c-Fms⁺RANK⁻ cells).

The differentiation of osteoclasts is inhibited by GM-CSF through reduction of c-Fos expression. By contrast, dendritic cell maturation induced by GM-CSF and sRANKL is inhibited by expression of c-Fos or M-CSF.