CFU-Cs in BM.

Figure shows the proportion of injected CFU-Cs that lodged in BM (total BM calculated as described in “Materials and methods”) when donor BM cells from EPL^−/− or double-positive mice were given to either double-positive or EPL^−/− or EP^−/− irradiated recipients. Ten double-positive mice and 10 EPL^−/− mice were given cells from EPL^−/−donors and half were killed at 3 hours, the other half at 48 hours after infusion (left panel). At 3 hours an additional group of 9 recipient EPL^−/− animals (5 + 9 = 14) and 5 EP^−/− recipient animals were evaluated in separate experiments and are included in this figure. Another group of 20 animals, 10 double-positive recipients and 10 EPL^−/−recipients were given double-positive cells from the same BM pool; half were killed at 24 hours and the rest at 72 hours (right panel). None of the differences between control (double-positive) cells or selectin-deficient (double-negative) cells given to double-positive or double-negative recipients were statistically significant (P ≥ .05).