In vivo effects of IVIG infusion on endogenous immunoglobulin levels in mice.

IVIG was given at a dose of 1.8 g/kg body weight (black dots). Control animals (open circles) received an equivalent volume of saline. The 6 panels show total IgG plasma concentration (in mg/mL), endogenous levels of mouse IgG1, IgG2a, IgG3, and IgM, and albumin (expressed as a percentage of the pre-infusion levels), respectively. The time scale is indicated below the lower 2 panels. Data represent mean ± SD (n = 4). **P < .01 and *P < .05 for difference IVIG and control group (t test).