Simulation of the clearance of intravenously injected tracer doses of IgG at different IgG plasma concentrations in humans.

Simulation concerns the administration of IgG at time zero, at a dose that did not increase the plasma IgG concentration. Plasma concentration of tracer IgG is expressed as a percentage of the concentration immediately after administration. The inset table shows the basal IgG plasma concentrations in milligrams per milliliter (IgG) used in the simulations shown and the half-lives in days (t_½) of the tracer IgG, calculated from the terminal parts of the generated curves.