Surface expression of TRAIL and TRAIL receptors on marrow cells and ratio of surface expression of TRAIL-R1 and R2 to TRAIL-R3 and R4.

(A) Surface expression of TRAIL and receptors R1 to R4 on marrow cells from 10 healthy donors (Healthy) and 20 patients with MDS (MDS). Shown are results for total marrow, CD3⁺, CD14⁺, CD13⁺, and CD34⁺ cells (mean ± 1 SD); β-actin served as internal standard. (B) Ratio of surface expression (as shown in part A) of TRAIL receptors R1 and R2 (agonistic) over R3 and R4 (decoy) in marrow from 10 healthy donors and from 20 patients with MDS. Shown are the results (mean ± 1 SD) for total marrow and for CD3⁺, CD14⁺, CD13⁺, and CD34⁺ cells, respectively.