The apo(a) portion of Lp(a) binds TFPI.

(A) Binding of Lp(a) to rTFPI (▪) and albumin (∗) immobilized on polystyrene wells. (B) Representative dot-blot analysis of Lp(a) ultracentrifugation fractions following DTT reduction, showing Lp(a−) in fraction 4 and apo(a) in fractions 6 to 9. (C) TFPI binding of apo(a) (▪) and Lp(a−) (●) fractions obtained from 100 μg Lp(a) by DTT reduction and gradient ultracentrifugation. Data presented are the mean values from 3 separate experiments.