PLG binds TFPI and apo(a) inhibits this binding.

(A) Binding of varying concentrations of L-PLG to rTFPI in the presence (⋄) or absence (■) of EACA (0.2 M). (B) Binding of varying concentrations of L-PLG to rTFPI in the presence (♦) or absence (■) of apo(a) (500 nM). (C) Western blot showing lack of cross-reactivity between anti-PLG and anti-apo(a) antibodies. In panels A and B data presented are the mean values from 3 separate experiments.