Lp(a) decreases rTFPI activity in fluid phase.

(A) Lp(a) decreases rTFPI activity in a dose-dependent manner in the presence (shaded bars) or absence of 2 μM L-PLG (filled bars) following coincubation for 30 minutes at 37°C. (B) Normal sequence cTFPI₃₇ (c-term) attenuates Lp(a) inhibition of rTFPI activity to a significantly greater extent than cTFPIs (scrambled peptide). Data presented are the means from at least 3 separate experiments; * indicates P < .01; ** indicatesP < .05.