Th lymphocyte subpopulations in PHI patients.

Absolute cell counts of CD4⁺ (A), LHP (CD62L⁺CD45RO⁺) Th cells (B), and NLHP (CD62L⁻CD45RO⁺) Th cells (C) and the percentage of CCR5-expressing LHP Th cells (D), CCR5-expressing NLHP Th cells (E), and α₄β₇-expressing Th cells (F) were determined at inclusion in 12 PHI patients (hollow boxes) and 12 age-matched healthy controls (solid boxes). Box plots depict median (horizontal line within box), 75% to 25% IQR (upper and lower limits of the box, respectively), and range (upper and lower horizontal bars outside the box). (G) Dot plots of β₇-integrin staining of CD4⁺ T cells of a representative control individual and a selected PHI patient. *P < .05; **P < .005 by 2-tailed Student ttest.