Fig. 10.
Fig. 10. Methemoglobin formation in whole blood during incubation with GOLs. / Values are shown for SPS liposome-types (EPC:SPS:Chol, 4:3:3 mole ratio, lipid concentration 1 mM). Whole blood and PBS/glucose, respectively, were incubated with different concentrations of GOLs (2, 0.2, and 0.002 U/mL GO; 10, 1, 0.01 mM total lipid concentration). Shown are the means of 3 unrelated experiments with different healthy donors (CV < 0.27); ▪ indicates whole blood with liposomes (10 mM lipid; 2 U/mL GO); ■, PBS/Gluc plus GOLs (10 mM lipid; 2 U/mL GO); ●, whole blood with liposomes (1 mM lipid; 0.2 U/mL GO); ○, PBS/Gluc plus GOLs (1 mM lipid; 0.2 U/mL GO); ▴, whole blood with liposomes (0.01 mM lipid; 0.002 U/mL GO); ▵, PBS/Gluc plus GOLs (0.01 mM lipid; 0.002 U/mL GO).

Methemoglobin formation in whole blood during incubation with GOLs.

Values are shown for SPS liposome-types (EPC:SPS:Chol, 4:3:3 mole ratio, lipid concentration 1 mM). Whole blood and PBS/glucose, respectively, were incubated with different concentrations of GOLs (2, 0.2, and 0.002 U/mL GO; 10, 1, 0.01 mM total lipid concentration). Shown are the means of 3 unrelated experiments with different healthy donors (CV < 0.27); ▪ indicates whole blood with liposomes (10 mM lipid; 2 U/mL GO); ■, PBS/Gluc plus GOLs (10 mM lipid; 2 U/mL GO); ●, whole blood with liposomes (1 mM lipid; 0.2 U/mL GO); ○, PBS/Gluc plus GOLs (1 mM lipid; 0.2 U/mL GO); ▴, whole blood with liposomes (0.01 mM lipid; 0.002 U/mL GO); ▵, PBS/Gluc plus GOLs (0.01 mM lipid; 0.002 U/mL GO).

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