Primary splenic lymphocytes from

Fancg^−/− mice have increased DEB- and MMC-induced chromosome breakage. (A) Comparison of the number of aberrations per cell after treatment with the indicated amount of DEB or MMC. (B) Metaphase spreads of splenocytes fromFancg^+/− and Fancg^−/−mice after 72 hours of in vitro growth. Cells were exposed to either no drug (+0), MMC (20 ng/mL), or IR (4 Gy). Arrows indicate radial forms or breaks.