The model for Myb LZR activity in commitment of hematopoietic progenitors.

Scheme for the development of wild-type v-Myb and LZR mutant v-Myb (LZRm v-Myb) cells into various lineages. Macrophage (Mac), heterophilic granulocyte (Gra), eosinophil (Eos), erythrocyte (Ery), and thrombocyte (Thr). Horizontal bars denote strong (bold) or partial (gray) differentiation block induced by Myb proteins. Arrows indicate self-renewing potential of cells. (B) Model for regulation of lineage choice by c-Myb conformers based on biologic properties of v-Myb molecules (upper part) described in this paper. DNA binding domain (DBD), transactivation domain (TA), leucine zipper region (LZR), EVES domain.51