Fig. 4.
Strand specificity of de novo methylation.
Methylation analysis of the proximal transcribed region of theρ-globin gene in day 5, day 6, and day 8 embryonic erythroid cells on both DNA strands. Methylation is seen on the coding (top) strand only in day 5 and day 6 erythroid cells. Arrows indicate cytosine residues at CpG dinucleotides. Positions indicated are relative to the transcription start site.