Fig. 5.
PP14.Fcγ1 increases OKT3 dose required for T-cell activation.
Purified T cells were stimulated with increasing amounts of solid-phase OKT3 mAbs either alone (♦), in conjunction with anti-CD28 mAb (▪), in conjunction with anti-CD28 mAb plus AF (12.5% vol/vol; ■), or in conjunction with anti-CD28 mAb plus purified PP14 · Fcγ1 (48 μg/mL; ▵). [3H]-thymidine incorporation was determined 72 hours later as described in the legend for Figure 1. Comparable results were obtained in 3 experiments.