Two pathways of gastric MZBCL of MALT-type development from normal cells (NC).

The first one is characterized by the t(11;18); peculiarly, these lymphomas only rarely accumulate additional genetic aberrations and do not seem to transform into DLBCL. On the other side, the t(11;18)-negative tumors acquire various genetic aberrations exemplified by the 3q26.2-27 amplification, and some of them may eventually transform into high-grade DLBCL (listed are some of the most common additional aberrations). The 6q aberration displaying cases might be primary DLBCL.