The effect of OPG on cancellous bone area in mice bearing 5T2MM myeloma cells.

(A) Section of the femur from a control, uninjected animal. (B) Section of the femur from an animal injected with 5T2MM cells and vehicle, showing the decrease in cancellous bone area. (C) Section of the femur from an animal injected with 5T2MM cells and treated with OPG. (D) Cancellous bone area as a percentage of total area in the femora of control animals, animals injected with 5T2MM cells and vehicle, and animals injected with 5T2MM cells and OPG. (E) Cancellous bone area as a percentage of total area in the tibiae of control animals, animals injected with 5T2MM cells and vehicle, and animals injected with 5T2MM cells and OPG. Original magnification × 1.6.