Fig. 5.
Fig. 5. The effect of OPG on TRAP-positive osteoclast formation in mice bearing 5T2MM myeloma cells. / (A) Section of the tibia from a control, uninjected animal. (B) Section of the tibia from an animal injected with 5T2MM cells and vehicle, showing large numbers of TRAP-positive cells lining the endocortical surface area. (C) Section of the femur from an animal injected with 5T2MM cells and treated with OPG. (D) Osteoclast numbers in the tibiae of control animals, animals injected with 5T2MM cells and vehicle, and animals injected with 5T2MM cells and treated with OPG. Original magnification × 20.

The effect of OPG on TRAP-positive osteoclast formation in mice bearing 5T2MM myeloma cells.

(A) Section of the tibia from a control, uninjected animal. (B) Section of the tibia from an animal injected with 5T2MM cells and vehicle, showing large numbers of TRAP-positive cells lining the endocortical surface area. (C) Section of the femur from an animal injected with 5T2MM cells and treated with OPG. (D) Osteoclast numbers in the tibiae of control animals, animals injected with 5T2MM cells and vehicle, and animals injected with 5T2MM cells and treated with OPG. Original magnification × 20.

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