Effects of rhTIMP-1 and rhTIMP-2 on T-cell cytotoxicity.

Effects of rhTIMP-1 and rhTIMP-2 on T-cell cytotoxicity against autologous phytohemagglutinin-stimulated lymphocytes pulsed with a melanoma-associated peptide, Ile-Met-Asp-Gln-Val-Pro-Phe-Ser-Val (one representative experiment, left panel) and in allogeneic mixed lymphocyte reactions (3 experiments, right panel). Open triangles indicate controls without TIMP; solid symbols represent assays with either rhTIMP-1 or rhTIMP-2 (triangle) present. Values are means from triplicate experiments. Values for TIMPs at the highest effector-to-target ratios were significantly different from control values.