Fig. 1.
A schematic diagram of the FLT3 receptor tyrosine kinase.
The extracellular domain is labeled and shaded light gray, arrows point to the transmembrane (hatched box) and juxtamembrane domains, and the 2 protein kinase domains (PTK) are shaded dark gray and labeled. The amino acid sequence of exon 11, which encodes the juxtamembrane sequence, is shown below. WT is the wild-type sequence and W78, W73, W51, Npos, and T6 are the FLT3-ITD mutations where the duplicated residues are shown, together with an arrow indicating the duplication position with respect to wild-type exon 11. The amino terminus is labeled NH2 and the carboxy terminus is labeled COOH.
