Effect of the Src-family kinase inhibitor PP1 on migration of CD8⁺ T cells.

CD8⁺ T cells were costimulated for 3 days, stained with Calcein-AM, and left untreated or treated with 5 μM PP1. At this time, 32% of cells expressed CD4. Results are the percentage of cells migrating in response to IL-16 or MIP1α compared with medium-only (no inhibitor) controls. Asterisks indicate samples with levels of migration to the designated chemotactic factor after treatment with PP1 that were significantly different from levels of samples treated with the same chemotactic factor alone (P < .05).