Effect of transplantation on peripheral blood CD4 count and viral load.

Data for patient 1 are represented by dashed lines and symbols, and for patient 2 by solid lines and symbols. The CD4 count in cells per microliter is represented by squares for both patients and is plotted along the left y-axis. The circles represent the viral load in copies per milliliter, which is plotted along the right y-axis. Both variables are plotted against the days after transplantation. The horizontal lines represent the days of HAART therapy, and the horizontal arrows represent the beginning of the immunosuppression taper. The vertical arrow shows the commencement of interferon, and the arrowhead, the day of donor lymphocyte infusion given to patient 2. Patient 2 died 12 months after transplantation. The CD4 count for both patients remained at or above what it was prior to transplantation. The viral load remained undetectable at the latest time point measured.