American Society of Hematology

Fig. 4.

$Fig. 4. Effect of STI571 on proliferating Ph+CD34+ cells—CML 7, example 1. / These dot-plots show representative results for a CML sample that proved to be highly sensitive to STI571. As shown in the upper left dot-plot, in the presence of added growth factors, the CD34+ cells were stimulated to proliferate up to 6 times, with associated loss of CD34 expression induced by differentiation. The addition of STI571 (upper right) eradicated almost all the dividing cells, leaving behind only the nonproliferating quiescent fraction. In the absence of growth factors (lower left), the CD34+ cells demonstrated autonomous growth (compared with the normal control in Figure 3) with up to 4 divisions and with retention of CD34 expression. The addition of STI571 (lower right) once again eradicated all cells that entered cell division.$

Effect of STI571 on proliferating Ph⁺CD34⁺ cells—CML 7, example 1.

These dot-plots show representative results for a CML sample that proved to be highly sensitive to STI571. As shown in the upper left dot-plot, in the presence of added growth factors, the CD34⁺ cells were stimulated to proliferate up to 6 times, with associated loss of CD34 expression induced by differentiation. The addition of STI571 (upper right) eradicated almost all the dividing cells, leaving behind only the nonproliferating quiescent fraction. In the absence of growth factors (lower left), the CD34⁺ cells demonstrated autonomous growth (compared with the normal control in Figure 3) with up to 4 divisions and with retention of CD34 expression. The addition of STI571 (lower right) once again eradicated all cells that entered cell division.

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