Fig. 5.
Fig. 5. Effect of selective ET-1 receptor antagonists on ET-1–induced Gardos activity in normal and sickle erythrocytes. / Human red cells were preincubated with and without 500 nM ET-1 and antagonists for 20 minutes at 37°C in isotonic sodium medium. K+ influx was measured in a medium containing 1 μM Ca++ ionized and 5 μM A23187 in the presence of ET-1 or selective antagonists with and without 500 nM ChTX. BQ123, a selective ETA receptor antagonist; BQ788, a selective ETBreceptor antagonist. Values are expressed as mean ± SE of 3 experiments. *P < .04 (control vs ET-1); **P < .04 (ET-1 vs BQ788).

Effect of selective ET-1 receptor antagonists on ET-1–induced Gardos activity in normal and sickle erythrocytes.

Human red cells were preincubated with and without 500 nM ET-1 and antagonists for 20 minutes at 37°C in isotonic sodium medium. K+ influx was measured in a medium containing 1 μM Ca++ ionized and 5 μM A23187 in the presence of ET-1 or selective antagonists with and without 500 nM ChTX. BQ123, a selective ETA receptor antagonist; BQ788, a selective ETBreceptor antagonist. Values are expressed as mean ± SE of 3 experiments. *P < .04 (control vs ET-1); **P < .04 (ET-1 vs BQ788).

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