Osteoclastogenesis induced by ATL cells.

HPCs were cocultured with ATL cells of patients with hypercalcemia (cases 1 and 3 in Tables 1 and 2), and those without hypercalcemia (cases 10 and 15). Experiments were performed by using HPCs from different healthy volunteers (A and B). (A) 1 indicates case 1; 2, case 3; 3, Case 15; 4, CD3⁺ T-lymphocytes from a healthy volunteer; 5, M-CSF only; and 6, sRANKL + M-CSF. (B) 1 indicates case 1; 2, case 3; 3, case 10; 4, case 15; 5, CD3⁺ lymphocytes from a healthy volunteer; 6, M-CSF only; and 7, sRANKL + M-CSF.