Lack of effect of an SDF-1 antagonist on the level of human cell engraftment in NOD/SCID mice.

The number of different types of human cells present in the marrow of NOD/SCID mice was assessed 10 to 12 weeks after their transplantation with human marrow cells and 1 day after 2 daily injections of 10 μg SDF-1(G2) (▪) or PBS (■) per mouse. Values are the mean ± SEM of the total number of each human cell type determined in 6 experiments. In each of these experiments, groups of 2 to 4 mice were injected with cells from a different normal marrow sample. No significant difference (P > .05) between controls and SDF-1(G2)–treated animals was observed for any of the cell types examined.