Immunohistochemical staining of bone marrow sections.

Microvascular endothelial cells were highlighted by antibodies against thrombomodulin. The bone marrow biopsies were taken from patient no. 11 with AML before (panel A) and 1 month after (panel B) treatment with thalidomide. Note the visible reduction in microvessel density of the bone marrow during thalidomide treatment in this patient with a partial response. Original magnification × 500.