Plasma AGP levels in CML.

(A) AGP plasma levels in CML patients at different disease stages. At diagnosis, mean AGP level was 1.22 ± 0.12 mg/mL (mean ± SEM; n = 13); in conventionally treated CML patients, 1.02 ± 0.07 mg/mL (n = 49); and in accelerated phase/blast crisis, 1.32 ± 0.14 mg/mL (n = 21). The mean plasma AGP level in normal controls was 0.62 ± 0.04 mg/mL (n = 7). (B) The effect of STI571 treatment on plasma AGP levels in chronic phase (CP) and accelerated phase/blast crisis (AP/BC) CML patients. The mean plasma AGP levels in 16 CML patients in CP measured prior to STI571 monotherapy was 0.91 ± 0.08 mg/mL. At 4 weeks into treatment, the mean AGP plasma in these same patients was found to be 1.06 ± 0.11 mg/mL; 5 of the 16 were followed to week 8 when mean AGP plasma level was 0.94 ± 0.12 mg/mL. In 8 AP/BC patients, the baseline AGP plasma level prior to STI571 therapy was 1.25 ± 0.19 mg/mL, and 4 weeks later it was 1.10 ± 0.19 mg/mL.