PNU156804 blocks allograft damage to myocytes and reduces infiltration of polymorphonuclear cells.

BUF heart allografts were harvested and examined on day after grafting from WF recipients that received alternate-day oral gavage of DMSO vehicle alone (A) or vehicle with 80 mg/kg PNU156804 (B). The presented sections were obtained after uniform histologic analysis of 3 hearts for each experimental group, with 12 horizontal cuts made on each heart. Each section was scored using the Society of Heart and Lung Transplantation system. See “Materials and methods” for details. Original magnification, × 200.