TF titration in normal blood and “acquired” hemophilia B blood.

Clotting of CTI-inhibited (0.1 mg/mL) normal blood (●) and acquired hemophilia B blood at various TF concentrations. Factor VIIa at concentrations of 0 (♦), 10 (∗), and 50 nM (▵) was added to the hemophilia B blood. Panel A shows clotting times; panel B, maximum TAT levels; and panel C, maximum osteonectin levels.