TF-initiated clotting of normal blood and congenital hemophilia A blood in the presence of factor VIIa.

Clotting of CTI-inhibited (0.1 mg/mL) normal blood initiated with 12.5 pM TF (▪) and addition of 10 nM factor VIIa (▴) and of hemophilia A blood with (♦) and without (●) addition of 10 nM factor VIIa. Panel A shows TAT generation over time; panel B, FPA release; panel C, FPB release; and panel D, osteonectin release. Arrows indicate clotting times.