Up-regulation of TSP-2 expression in cutaneous inflammation.

Differential immunofluorescent staining for CD31 (green) and TSP-2 (red) in normal wild-type mouse skin (A) revealed several TSP-2–expressing nonendothelial cells within the dermis but only a few TSP-2–positive blood vessels (yellow, arrow). (B) Twenty-four hours after oxazolone challenge the TSP-2 expression is up-regulated in fibroblasts, and an increased number of TSP-2–positive blood vessels (yellow, arrows) were observed. Scale bar = 100 μm.