Endogenous IL-10 is required for SDF-1–induced cytoskeleton rearrangement.

Peritoneal cells were labeled with CD19, CD5, and Mac-1 mAbs and tested by flow cytometry for SDF-1–induced cytoskeleton rearrangement. This effect was tested with an anti–IL-10R Ab (black squares) or a control Ab (gray triangles), or without Ab addition (empty diamonds). Results (mean ± SEM from 3 experiments) show the kinetics of actin polymerization following SDF-1 addition. 100% corresponds to the baseline level.