Opposite effects of IL-10 on SDF-1–induced and BLC-induced chemotaxis.

Peritoneal cells were labeled with CD19, CD5, and Mac-1 mAbs and tested in Transwell experiments for SDF-1–induced or BLC-induced chemotaxis. Migration was evaluated without (empty columns) or with IL-10 (black columns), with a control Ab (gray columns), or with an anti–IL-10R Ab (hatched columns). Results (mean ± SEM from 3 experiments) are the numbers of cells migrating to the lower chamber.