Fig. 3.
Fig. 3. Key role of IL-12 and IL-18 in serum IFN-γ induction by α-GalCer. / Serum was collected from B6 WT (■) or anti-asGM1–treated B6 WT mice (●), B6 Jα281−/− mice (▴), B6 IL-12−/− mice (○), or B6 IL-18−/− mice (▵) after α-GalCer (2 μg intraperitoneally) administration at the times indicated. Serum IFN-γ levels were measured by a specific enzyme-linked immunosorbent assay, and data represent the mean ± SE (ng/mL) of duplicate samples from 2 different mice. Serum of all untreated mice contained less than 100 pg/mL IFN-γ.

Key role of IL-12 and IL-18 in serum IFN-γ induction by α-GalCer.

Serum was collected from B6 WT (■) or anti-asGM1–treated B6 WT mice (●), B6 Jα281−/− mice (▴), B6 IL-12−/− mice (○), or B6 IL-18−/− mice (▵) after α-GalCer (2 μg intraperitoneally) administration at the times indicated. Serum IFN-γ levels were measured by a specific enzyme-linked immunosorbent assay, and data represent the mean ± SE (ng/mL) of duplicate samples from 2 different mice. Serum of all untreated mice contained less than 100 pg/mL IFN-γ.

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