Fig. 2.
Fig. 2. ATF4−/− embryos are anemic. / (A) Gross appearance of 15.5-dpc embryos. The ATF4−/−embryo (right) is paler and smaller than a wild-type littermate (left). The pupils of ATF4−/− embryos are smaller. The gross appearance is otherwise normal. (B) Hematocrit values for ATF4+/+ (n = 35), ATF4+/− (n = 51), and ATF4−/− (n = 29) 15.5-dpc embryos. Error bars represent SEM. The mean hematocrit values for ATF4−/− 15.5-dpc embryos were significantly lower (P < .0001) than those for either ATF4+/+ or ATF4+/−embryos.

ATF4−/− embryos are anemic.

(A) Gross appearance of 15.5-dpc embryos. The ATF4−/−embryo (right) is paler and smaller than a wild-type littermate (left). The pupils of ATF4−/− embryos are smaller. The gross appearance is otherwise normal. (B) Hematocrit values for ATF4+/+ (n = 35), ATF4+/− (n = 51), and ATF4−/− (n = 29) 15.5-dpc embryos. Error bars represent SEM. The mean hematocrit values for ATF4−/− 15.5-dpc embryos were significantly lower (P < .0001) than those for either ATF4+/+ or ATF4+/−embryos.

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