Fig. 4.
Fig. 4. Caspase expression in fresh GpA. / +dim and GpA+brighterythroblasts. FLICE was greatly accumulated in GpA+dim cells from group A, whereas both ICE and caspase-10 occurred at significantly higher values in their GpA+brighterythroblasts than in group B. Although the analysis evaluated the extent of proenzyme caspases, the differential accumulation of these proteases in fresh erythroid cells suggested the occurrence in vivo of separate apoptotic stimuli through Fas in immature erythroblasts, and TRAIL receptors as the maturation progresses. Data are expressed as mean ± SD of double-fluorescence analysis. (B) Flow cytometric pattern of caspase expression in GpA+dim (green) and GpA+bright (red) erythroblasts in a representative anemic (A-14) and a nonanemic (B-07) patient. The percentages indicate the number of positive cells within each erythroblast subset.

Caspase expression in fresh GpA

+dim and GpA+brighterythroblasts. FLICE was greatly accumulated in GpA+dim cells from group A, whereas both ICE and caspase-10 occurred at significantly higher values in their GpA+brighterythroblasts than in group B. Although the analysis evaluated the extent of proenzyme caspases, the differential accumulation of these proteases in fresh erythroid cells suggested the occurrence in vivo of separate apoptotic stimuli through Fas in immature erythroblasts, and TRAIL receptors as the maturation progresses. Data are expressed as mean ± SD of double-fluorescence analysis. (B) Flow cytometric pattern of caspase expression in GpA+dim (green) and GpA+bright (red) erythroblasts in a representative anemic (A-14) and a nonanemic (B-07) patient. The percentages indicate the number of positive cells within each erythroblast subset.

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